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Allergic reaction or anaphylaxis was reported in 26 of 8680 participants (0.3%) after 1 dose of the BNT162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna) vaccine, 27 of 11 141 (0.2%) after 2 doses of the BNT162b2 or mRNA-1273 vaccine or 1 dose of the JNJ-78436735 (Johnson & Johnson) vaccine. Results The 19 586 participants had a median (IQR) age of 54 (38-66) years, and 13 420 (68.8%) were women. Candidate factors in multivariable logistic regression models included age, sex, race, ethnicity, subjective social status, prior COVID-19 infection, medical conditions, substance use, vaccine dose, and vaccine brand. Main Outcomes and Measures Participant-reported adverse effects and adverse effect severity.

This analysis includes participants who provided consent between March 26, 2020, and May 19, 2021, and received at least 1 COVID-19 vaccine dose.Įxposures Participant-reported COVID-19 vaccination. Participants complete daily, weekly, and monthly surveys on health and COVID-19–related events. Objective To evaluate factors potentially associated with participant-reported adverse effects after COVID-19 vaccination.ĭesign, Setting, and Participants The COVID-19 Citizen Science Study, an online cohort study, includes adults aged 18 years and older with a smartphone or internet access. Importance Little is known about the factors associated with COVID-19 vaccine adverse effects in a real-world population. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.